Precision Medicine lab
The Precision Medicine Lab is a joint initiative of Rehman Medical Institute and CECOS University and is
an affiliate lab is of the National Centre for Big Data and Cloud Computing funded by Higher Education
Commission, under the Federal Government. The lab is led by the Oxford-trained biologist, Dr. Faisal
Khan, who brings in a strong inter-disciplinary and translational approach to the research done in the Lab.
The over-arching aim of the Lab is to 1) help create a knowledgebase of local patients and their unique mutational signature that can be biomarkers of diagnostic, prognostic or therapeutic value, and also 2) help consultants and practitioners adopt existing genomic data and established molecular signatures in their current practice. We have started with oncology, and oral squamous cell carcinoma specifically, but we intend to expand into other areas over the coming months.
The Lab opened its doors in September 2018, and operates autonomously under a Steering Committee. The lab employs 20+ cell and molecular biologists, data scientists and clinicians working together under the same roof.
Brief Explanation of Services
The Precision Medicine Lab can offer the following to its community:
For consultants and medical doctors:
- We can help you identify genes and mutations to look out for in your disease(s) of interest when dealing with your patients.
- We can develop genetic and genomic tests specific to the conditions you are interested in that you can prescribe to your patients and make better decisions during their treatment.
- We can help you interpret results from genetic or genomic testing, especially in complex cases.
For patients and their families:
- You can always enroll in any of our undergoing studies to study your condition and decipher the genetic details of the disease. You can do this by donating your samples that we may require. Results from such studies may or may not be of direct help to you, but will certainly enhance our knowledge about the disease for future use in other patients. We only accept samples via your doctor, therefore, for all medical advice please consult your doctor. Current studies that you can join are as follows:
- [August 17, 2020] Whole exome analysis of Oral Squamous Cell Carcinoma in Pakistani patients.
- You can also join our mailing lists and attend our public events to keep yourself up to date on our latest research and upcoming studies in the future.
For researchers and students
We are always on the look for great collaborators and thesis students who can work in our lab. Apart of collaborations in areas of mutual interest, researchers can benefit from our state-of-the-art biorepository, next generation sequencing, bioinformatics analysis, human cell culture and functional/drug assays in 2D and 3D cell cultures.
Researchers can approach our PI directly at [email protected].
Students and interns can email our Community Lead at [email protected].
The Lab leverages both the Illumina and Nanopore based DNA sequencing, 2D and 3D cell culture methods for human cell lines for its research. The lab also houses a state-of-the-art biorepository for banking patient samples including DNA/RNA, blood and tissue biopsies.
Dr Faisal Kha
Dr Johar Ali
Shahram Yusuf Khan
Umair Wali Khan
The Precision Medicine Lab itself is Pakistan’s first pilot in the area of Precision Medicine, to learn and explore how we can enhance patient care, in the area of Oral Cancer to begin with.
The initial draft of the Whole Exome Study of Oral Squamous Cell Carcinoma patients is expected by the end of Q2 in 2021.
Currently we are investigating the following, especially in the local population: Head and Neck Cancer; Oral Squamous Cell Carcinoma; Breast and Ovarian Cancer; Hematological Malignancies.Consultants can get in touch with Dr. Faisal Khan for potential collaborations for molecular and genomic studies of other cancers or diseases.
1 central translational research laboratory
20+ biologists and biotechnologists, data scientists and clinicians
1000+ local cancer patients being recruited3,200,000,000 bases of DNA from each patient under study!